Sequestration of multiple RNA recognition motif-containing proteins by C9orf72 repeat expansions

GGGGCC repeat expansions of C9orf72 represent the most common genetic variant of amyotrophic lateral sclerosis and frontotemporal degeneration, but the mechanism of pathogenesis is unclear. Recent reports have suggested that the transcribed repeat might form toxic RNA foci that sequester various RNA...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Cooper-Knock, Johnathan, Walsh, Matthew J., Higginbottom, Adrian, Robin Highley, J., Dickman, Mark J., Edbauer, Dieter, Ince, Paul G., Wharton, Stephen B., Wilson, Stuart A., Kirby, Janine, Hautbergue, Guillaume M., Shaw, Pamela J.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Oxford University Press 2014
विषय:
Original Articles
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4065024/
https://ncbi.nlm.nih.gov/pubmed/24866055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awu120
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