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Acceleration of an aldo-keto reductase by minimal loop engineering
Aldo-keto reductases tighten coenzyme binding by forming a hydrogen bond across the pyrophosphate group of NAD(P)(H). Mutation of the hydrogen bonding anchor Lys24 in Candida tenuis xylose reductase prevents fastening of the “safety belt” around NAD(H). The loosened NAD(H) binding leads to increased...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4064709/ https://ncbi.nlm.nih.gov/pubmed/24951537 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzu021 |
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