Aldo-Keto Reductases in the Eye

Aldose reductase (AKR1B1) is an NADPH-dependent aldo-keto reductase best known as the rate-limiting enzyme of the polyol pathway. Accelerated glucose metabolism through this pathway has been implicated in diabetic cataract and retinopathy. Some human tissues contain AKR1B1 as well as AKR1B10, a clos...

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Bibliographic Details
Main Authors: Huang, Shun Ping, Palla, Suryanarayana, Ruzycki, Philip, Varma, Ross Arjun, Harter, Theresa, Reddy, G. Bhanuprakesh, Petrash, J. Mark
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2902055/
https://ncbi.nlm.nih.gov/pubmed/20628518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2010/521204
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