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Aldo-Keto Reductases and Cancer Drug Resistance

Human aldo-keto reductases (AKRs) catalyze the NADPH-dependent reduction of carbonyl groups to alcohols for conjugation reactions to proceed. They are implicated in resistance to cancer chemotherapeutic agents either because they are directly involved in their metabolism or help eradicate the cellul...

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Podrobná bibliografie
Vydáno v:Pharmacol Rev
Hlavní autoři: Penning, Trevor M., Jonnalagadda, Sravan, Trippier, Paul C., Rižner, Tea Lanišnik
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8318518/
https://ncbi.nlm.nih.gov/pubmed/34312303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/pharmrev.120.000122
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