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Aldo-Keto Reductases and Cancer Drug Resistance

Human aldo-keto reductases (AKRs) catalyze the NADPH-dependent reduction of carbonyl groups to alcohols for conjugation reactions to proceed. They are implicated in resistance to cancer chemotherapeutic agents either because they are directly involved in their metabolism or help eradicate the cellul...

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Bibliografski detalji
Izdano u:Pharmacol Rev
Glavni autori: Penning, Trevor M., Jonnalagadda, Sravan, Trippier, Paul C., Rižner, Tea Lanišnik
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Pharmacology and Experimental Therapeutics 2021
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8318518/
https://ncbi.nlm.nih.gov/pubmed/34312303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/pharmrev.120.000122
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