Acceleration of an aldo-keto reductase by minimal loop engineering

Aldo-keto reductases tighten coenzyme binding by forming a hydrogen bond across the pyrophosphate group of NAD(P)(H). Mutation of the hydrogen bonding anchor Lys24 in Candida tenuis xylose reductase prevents fastening of the “safety belt” around NAD(H). The loosened NAD(H) binding leads to increased...

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Detaylı Bibliyografya
Asıl Yazarlar: Krump, C., Vogl, M., Brecker, L., Nidetzky, B., Kratzer, R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2014
Konular:
Short Communication
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4064709/
https://ncbi.nlm.nih.gov/pubmed/24951537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzu021
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