Grb10 Promotes Lipolysis and Thermogenesis by Phosphorylation-dependent Feedback Inhibition of mTORC1

Identification of key regulators of lipid metabolism and thermogenic functions has important therapeutic implications for the current obesity and diabetes epidemic. Here we show that Grb10, a newly identified direct substrate of mechanistic/mammalian target of rapamycin (mTOR), is expressed highly i...

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Bibliographic Details
Main Authors:	Liu, Meilian, Bai, Juli, He, Sijia, Villarreal, Ricardo, Hu, Derong, Zhang, Chuntao, Yang, Xin, Liang, Huiyun, Slaga, Thomas, Yu, Yonghao, Zhou, Zhiguang, Blenis, John, Scherer, Philipp E., Dong, Lily Q., Liu, Feng
Format:	Artigo
Language:	Inglês
Published:	2014
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4064112/ https://ncbi.nlm.nih.gov/pubmed/24746805 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2014.03.018
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Grb10 Promotes Lipolysis and Thermogenesis by Phosphorylation-dependent Feedback Inhibition of mTORC1

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