Quantitative Phosphoproteomic Analysis Identifies the Adaptor Protein Grb10 as an mTORC1 Substrate that Negatively Regulates Insulin Signaling

The evolutionarily conserved Ser-Thr kinase mTOR plays a critical role in regulating many pathophysiological processes. Functional characterization of the mTOR signaling pathways, however, has been hampered by the paucity of known substrates. We used large-scale quantitative phospho-proteomics exper...

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Detalhes bibliográficos
Main Authors: Yu, Yonghao, Yoon, Sang-Oh, Poulogiannis, George, Yang, Qian, Ma, Xiaoju Max, Villén, Judit, Kubica, Neil, Hoffman, Gregory R., Cantley, Lewis C., Gygi, Steven P., Blenis, John
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195509/
https://ncbi.nlm.nih.gov/pubmed/21659605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1199484
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