Grb10 Promotes Lipolysis and Thermogenesis by Phosphorylation-dependent Feedback Inhibition of mTORC1

Identification of key regulators of lipid metabolism and thermogenic functions has important therapeutic implications for the current obesity and diabetes epidemic. Here we show that Grb10, a newly identified direct substrate of mechanistic/mammalian target of rapamycin (mTOR), is expressed highly i...

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Autors principals: Liu, Meilian, Bai, Juli, He, Sijia, Villarreal, Ricardo, Hu, Derong, Zhang, Chuntao, Yang, Xin, Liang, Huiyun, Slaga, Thomas, Yu, Yonghao, Zhou, Zhiguang, Blenis, John, Scherer, Philipp E., Dong, Lily Q., Liu, Feng
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4064112/
https://ncbi.nlm.nih.gov/pubmed/24746805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2014.03.018
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