Ribosomal protein–Mdm2–p53 pathway coordinates nutrient stress with lipid metabolism by regulating MCD and promoting fatty acid oxidation

The tumor suppressor p53 has recently been shown to regulate energy metabolism through multiple mechanisms. However, the in vivo signaling pathways related to p53-mediated metabolic regulation remain largely uncharacterized. By using mice bearing a single amino acid substitution at cysteine residue...

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Hlavní autoři: Liu, Yong, He, Yizhou, Jin, Aiwen, Tikunov, Andrey P., Zhou, Lishi, Tollini, Laura A., Leslie, Patrick, Kim, Tae-Hyung, Li, Lei O., Coleman, Rosalind A., Gu, Zhennan, Chen, Yong Q., Macdonald, Jeffrey M., Graves, Lee M., Zhang, Yanping
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2014
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060669/
https://ncbi.nlm.nih.gov/pubmed/24872453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1315605111
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