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Nullifying the CDKN2A/B Locus Promotes Mutant K-ras Lung Tumorigenesis
Lung cancer commonly displays a number of recurrent genetic abnormalities and about 30% of lung adenocarcinomas carry activating mutations in the K-ras gene; often concomitantly with inactivation of tumor suppressor genes p16INK4A and p14ARF of the CDKN2A/B locus. However, little is known regarding...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4058359/ https://ncbi.nlm.nih.gov/pubmed/24618618 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-13-0620-T |
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