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Akt1 deletion prevents lung tumorigenesis by mutant K-ras

K-ras mutations are associated with smoking-induced lung cancer and poor clinical outcomes. In mice, K-ras mutations are sufficient to induce lung tumors, which require phosphoinoside-3-kinase (PI3K) and further downstream, mammalian target of rapamycin (mTOR) activation. However, the roles of indiv...

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Bibliografiske detaljer
Main Authors: Hollander, MC, Maier, CR, Hobbs, EA, Ashmore, AR, Linnoila, RI, Dennis, PA
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4133779/
https://ncbi.nlm.nih.gov/pubmed/21242979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.556
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