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Akt1 deletion prevents lung tumorigenesis by mutant K-ras
K-ras mutations are associated with smoking-induced lung cancer and poor clinical outcomes. In mice, K-ras mutations are sufficient to induce lung tumors, which require phosphoinoside-3-kinase (PI3K) and further downstream, mammalian target of rapamycin (mTOR) activation. However, the roles of indiv...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4133779/ https://ncbi.nlm.nih.gov/pubmed/21242979 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.556 |
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