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Discovery of Novel α4β2 Neuronal Nicotinic Receptor Modulators through Structure-Based Virtual Screening

[Image: see text] We performed a hierarchical structure-based virtual screening utilizing a comparative model of the human α4β2 neuronal nicotinic acetylcholine receptor (nAChR) extracellular domain. Compounds were selected for experimental testing based on structural diversity, binding pocket locat...

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Xehetasun bibliografikoak
Egile Nagusiak: Mahasenan, Kiran V., Pavlovicz, Ryan E., Henderson, Brandon J., González-Cestari, Tatiana F., Yi, Bitna, McKay, Dennis B., Li, Chenglong
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Chemical Society 2011
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4056858/
https://ncbi.nlm.nih.gov/pubmed/24936233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml2001714
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