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Discovery of benzamide analogs as negative allosteric modulators of human neuronal nicotinic receptors: Pharmacophore modeling and structure-activity relationship studies

The present study describes our ongoing efforts toward the discovery of drugs that selectively target nAChR subtypes. We exploited knowledge on nAChR ligands and their binding site that were previously identified by our laboratory through virtual screenings and identified benzamide analogs as a nove...

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Détails bibliographiques
Publié dans:Bioorg Med Chem
Auteurs principaux: Yi, Bitna, Long, Sihui, González-Cestari, Tatiana F., Henderson, Brandon J., Pavlovicz, Ryan E., Werbovetz, Karl, Li, Chenglong, McKay, Dennis B.
Format: Artigo
Langue:Inglês
Publié: 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4347880/
https://ncbi.nlm.nih.gov/pubmed/23757208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.03.082
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