Discovery of benzamide analogs as negative allosteric modulators of human neuronal nicotinic receptors: Pharmacophore modeling and structure-activity relationship studies

The present study describes our ongoing efforts toward the discovery of drugs that selectively target nAChR subtypes. We exploited knowledge on nAChR ligands and their binding site that were previously identified by our laboratory through virtual screenings and identified benzamide analogs as a nove...

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Vydáno v:Bioorg Med Chem
Hlavní autoři: Yi, Bitna, Long, Sihui, González-Cestari, Tatiana F., Henderson, Brandon J., Pavlovicz, Ryan E., Werbovetz, Karl, Li, Chenglong, McKay, Dennis B.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4347880/
https://ncbi.nlm.nih.gov/pubmed/23757208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.03.082
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