Discovery of benzamide analogs as negative allosteric modulators of human neuronal nicotinic receptors: Pharmacophore modeling and structure-activity relationship studies

The present study describes our ongoing efforts toward the discovery of drugs that selectively target nAChR subtypes. We exploited knowledge on nAChR ligands and their binding site that were previously identified by our laboratory through virtual screenings and identified benzamide analogs as a nove...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Bioorg Med Chem
Huvudupphovsmän: Yi, Bitna, Long, Sihui, González-Cestari, Tatiana F., Henderson, Brandon J., Pavlovicz, Ryan E., Werbovetz, Karl, Li, Chenglong, McKay, Dennis B.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4347880/
https://ncbi.nlm.nih.gov/pubmed/23757208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.03.082
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk