Effect of Novel Negative Allosteric Modulators of Neuronal Nicotinic Receptors on Cells Expressing Native and Recombinant Nicotinic Receptors: Implications for Drug Discovery

Allosteric modulation of nAChRs is considered to be one of the most promising approaches for drug design targeting nicotinic acetylcholine receptors (nAChRs). We have reported previously on the pharmacological activity of several compounds that seem to act noncompetitively to inhibit the activation...

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Detalhes bibliográficos
Main Authors: González-Cestari, Tatiana F., Henderson, Brandon J., Pavlovicz, Ryan E., McKay, Susan B., El-Hajj, Raed A., Pulipaka, Aravinda B., Orac, Crina M., Reed, Damon D., Boyd, R. Thomas, Zhu, Michael X., Li, Chenglong, Bergmeier, Stephen C., McKay, Dennis B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Pharmacology and Experimental Therapeutics 2009
Assuntos:
Neuropharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2682284/
https://ncbi.nlm.nih.gov/pubmed/18984653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.108.144576
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