Autophagy is a survival mechanism of acute myeloid leukemia precursors during dual mTORC2/mTORC1 targeting

PURPOSE: To examine whether induction of autophagy is a mechanism of leukemic cell resistance to dual mTORC1/mTORC2 inhibitors in AML leukemic progenitors. EXPERIMENTAL DESIGN: Combinations of different experimental approaches were used to assess induction of autophagy, including immunoblotting to d...

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Bibliografiske detaljer
Main Authors: Altman, Jessica K., Szilard, Amy, Goussetis, Dennis J., Sassano, Antonella, Colamonici, Marco, Gounaris, Elias, Frankfurt, Olga, Giles, Francis J., Eklund, Elizabeth A., Beauchamp, Elspeth, Platanias, Leonidas C.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4056773/
https://ncbi.nlm.nih.gov/pubmed/24610825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-3218
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