Dual targeting of acute myeloid leukemia progenitors by catalytic mTOR inhibition and blockade of the p110α subunit of PI3 kinase

The mammalian target of rapamycin (mTOR) and phosphoinositide-3-kinase (PI3K) pathways are often aberrantly activated in acute myeloid leukemia (AML) and play critical roles in proliferation and survival of leukemia cells. We provide evidence that simultaneous targeting of mTOR complexes with the ca...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Colamonici, Marco, Blyth, Gavin, Saleiro, Diana, Szilard, Amy, Bliss-Moreau, Meghan, Giles, Francis J., Altman, Jessica K., Beauchamp, Elspeth M., Platanias, Leonidas C.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4480735/
https://ncbi.nlm.nih.gov/pubmed/25823922
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