Targeting mTOR signaling pathways and related negative feedback loops for the treatment of acute myeloid leukemia

An accumulating understanding of the complex pathogenesis of acute myeloid leukemia (AML) continues to lead to promising therapeutic approaches. Among the key aberrant intracellular signaling pathways involved in AML, the phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin (PI3K/AKT/mTOR...

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Detalhes bibliográficos
Publicado no:Cancer Biol Ther
Main Authors: Carneiro, Benedito A, Kaplan, Jason B, Altman, Jessica K, Giles, Francis J, Platanias, Leonidas C
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622839/
https://ncbi.nlm.nih.gov/pubmed/25801978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2015.1026510
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