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Murine coagulation factor VIII is synthesized in endothelial cells

The primary cellular source of factor VIII (FVIII) biosynthesis is controversial, with contradictory evidence supporting an endothelial or hepatocyte origin. LMAN1 is a cargo receptor in the early secretory pathway that is responsible for the efficient secretion of factor V (FV) and FVIII to the pla...

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Détails bibliographiques
Auteurs principaux: Everett, Lesley A., Cleuren, Audrey C. A., Khoriaty, Rami N., Ginsburg, David
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4055920/
https://ncbi.nlm.nih.gov/pubmed/24719406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-02-554501
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