Murine coagulation factor VIII is synthesized in endothelial cells

The primary cellular source of factor VIII (FVIII) biosynthesis is controversial, with contradictory evidence supporting an endothelial or hepatocyte origin. LMAN1 is a cargo receptor in the early secretory pathway that is responsible for the efficient secretion of factor V (FV) and FVIII to the pla...

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Bibliographic Details
Main Authors: Everett, Lesley A., Cleuren, Audrey C. A., Khoriaty, Rami N., Ginsburg, David
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2014
Subjects:
Plenary Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4055920/
https://ncbi.nlm.nih.gov/pubmed/24719406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-02-554501
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