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A conditional knockout mouse model reveals endothelial cells as the principal and possibly exclusive source of plasma factor VIII
The cellular source of coagulation factor VIII (FVIII) remains controversial. Like many coagulation proteins, FVIII is produced in the liver, and FVIII synthesis has long been associated with hepatocytes. But extrahepatic synthesis also occurs, and mounting evidence suggests that hepatocytes are not...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4055921/ https://ncbi.nlm.nih.gov/pubmed/24705491 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-02-555151 |
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