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A conditional knockout mouse model reveals endothelial cells as the principal and possibly exclusive source of plasma factor VIII

The cellular source of coagulation factor VIII (FVIII) remains controversial. Like many coagulation proteins, FVIII is produced in the liver, and FVIII synthesis has long been associated with hepatocytes. But extrahepatic synthesis also occurs, and mounting evidence suggests that hepatocytes are not...

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Autori principali: Fahs, Scot A., Hille, Matthew T., Shi, Qizhen, Weiler, Hartmut, Montgomery, Robert R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4055921/
https://ncbi.nlm.nih.gov/pubmed/24705491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-02-555151
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