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A conditional knockout mouse model reveals endothelial cells as the principal and possibly exclusive source of plasma factor VIII
The cellular source of coagulation factor VIII (FVIII) remains controversial. Like many coagulation proteins, FVIII is produced in the liver, and FVIII synthesis has long been associated with hepatocytes. But extrahepatic synthesis also occurs, and mounting evidence suggests that hepatocytes are not...
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| Główni autorzy: | , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Society of Hematology
2014
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4055921/ https://ncbi.nlm.nih.gov/pubmed/24705491 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-02-555151 |
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