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A simple strategy for heritable chromosomal deletions in zebrafish via the combinatorial action of targeting nucleases
Precise and effective genome-editing tools are essential for functional genomics and gene therapy. Targeting nucleases have been successfully used to edit genomes. However, whole-locus or element-specific deletions abolishing transcript expression have not previously been reported. Here, we show her...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4054832/ https://ncbi.nlm.nih.gov/pubmed/23815890 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2013-14-7-r69 |
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