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Targeted chromosomal deletions in human cells using zinc finger nucleases
We present a novel approach for generating targeted deletions of genomic segments in human and other eukaryotic cells using engineered zinc finger nucleases (ZFNs). We found that ZFNs designed to target two different sites in a human chromosome could introduce two concurrent DNA double-strand breaks...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Cold Spring Harbor Laboratory Press
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2798833/ https://ncbi.nlm.nih.gov/pubmed/19952142 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.099747.109 |
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