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Targeted chromosomal deletions in human cells using zinc finger nucleases

We present a novel approach for generating targeted deletions of genomic segments in human and other eukaryotic cells using engineered zinc finger nucleases (ZFNs). We found that ZFNs designed to target two different sites in a human chromosome could introduce two concurrent DNA double-strand breaks...

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Autors principals: Lee, Hyung Joo, Kim, Eunji, Kim, Jin-Soo
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798833/
https://ncbi.nlm.nih.gov/pubmed/19952142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.099747.109
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