Targeted chromosomal cleavage and mutagenesis in Drosophila using zinc-finger nucleases.

Zinc-finger nucleases (ZFNs) are hybrids between a nonspecific DNA-cleavage domain and a DNA-binding domain composed of Cys(2)His(2) zinc fingers. Because zinc fingers can be manipulated to recognize a broad range of sequences, these enzymes have the potential to direct cleavage to arbitrarily chose...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Bibikova, Marina, Golic, Mary, Golic, Kent G, Carroll, Dana
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2002
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1462166/
https://ncbi.nlm.nih.gov/pubmed/12136019
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