A simple strategy for heritable chromosomal deletions in zebrafish via the combinatorial action of targeting nucleases

Precise and effective genome-editing tools are essential for functional genomics and gene therapy. Targeting nucleases have been successfully used to edit genomes. However, whole-locus or element-specific deletions abolishing transcript expression have not previously been reported. Here, we show her...

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Main Authors: Lim, Shimin, Wang, Yin, Yu, Xueyao, Huang, Yian, Featherstone, Mark S, Sampath, Karuna
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2013
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Method
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4054832/
https://ncbi.nlm.nih.gov/pubmed/23815890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2013-14-7-r69
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