Chromosomal deletions and inversions mediated by TALENs and CRISPR/Cas in zebrafish

Customized TALENs and Cas9/gRNAs have been used for targeted mutagenesis in zebrafish to induce indels into protein-coding genes. However, indels are usually not sufficient to disrupt the function of non-coding genes, gene clusters or regulatory sequences, whereas large genomic deletions or inversio...

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Bibliografiska uppgifter
Huvudupphovsmän: Xiao, An, Wang, Zhanxiang, Hu, Yingying, Wu, Yingdan, Luo, Zhou, Yang, Zhipeng, Zu, Yao, Li, Wenyuan, Huang, Peng, Tong, Xiangjun, Zhu, Zuoyan, Lin, Shuo, Zhang, Bo
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2013
Ämnen:
Methods Online
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3737551/
https://ncbi.nlm.nih.gov/pubmed/23748566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt464
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