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Chromosomal deletions and inversions mediated by TALENs and CRISPR/Cas in zebrafish
Customized TALENs and Cas9/gRNAs have been used for targeted mutagenesis in zebrafish to induce indels into protein-coding genes. However, indels are usually not sufficient to disrupt the function of non-coding genes, gene clusters or regulatory sequences, whereas large genomic deletions or inversio...
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| Auteurs principaux: | , , , , , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3737551/ https://ncbi.nlm.nih.gov/pubmed/23748566 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt464 |
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