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Synthesis and characterization of a high-affinity α(v)β(6)-specific ligand for in vitro and in vivo applications

The α(v)β(6) integrin is an attractive therapeutic target for several cancers due to its role in metastasis and its negligible expression in normal tissues. We previously identified a peptide from a phage-displayed peptide library that binds specifically to α(v)β(6). The tetrameric version of the pe...

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Bibliographic Details
Main Authors: Li, Shunzi, McGuire, Michael J., Lin, Mai, Liu, Ying-Horng, Oyama, Tsukasa, Sun, Xiankai, Brown, Kathlynn C.
Format: Artigo
Language:Inglês
Published: 2009
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4053473/
https://ncbi.nlm.nih.gov/pubmed/19435868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-08-1098
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