Structural and Functional Correlates of Enhanced Anti-viral Immunity Generated by Heteroclitic CD8 T Cell Epitopes()

Peptides that bind poorly to MHC class I molecules often elicit low functional avidity T cell responses. Peptide modification by altering the anchor residue facilitates increased binding affinity and may elicit T cells with increased functional avidity towards the native epitope (“heteroclitic”). Th...

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Autori principali: Trujillo, Jonathan A., Gras, Stephanie, Twist, Kelly-Anne, Croft, Nathan P., Channappanavar, Rudragouda, Rossjohn, Jamie, Purcell, Anthony W., Perlman, Stanley
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4052115/
https://ncbi.nlm.nih.gov/pubmed/24795457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1400111
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