Epitope-specific TCRβ repertoire diversity imparts no functional advantage on the CD8(+) T cell response to cognate viral peptides

TCR repertoire diversity has been convincingly shown to facilitate responsiveness of CD8(+) T cell populations to mutant virus peptides, thereby safeguarding against viral escape. However, the impact of repertoire diversity on the functionality of the CD8(+) T cell response to cognate peptide-MHC cl...

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Detalhes bibliográficos
Main Authors: La Gruta, Nicole L., Thomas, Paul G., Webb, Andrew I., Dunstone, Michelle A., Cukalac, Tania, Doherty, Peter C., Purcell, Anthony W., Rossjohn, Jamie, Turner, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2538877/
https://ncbi.nlm.nih.gov/pubmed/18238896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711682102
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