Complete modification of TCR specificity and repertoire selection does not perturb a CD8(+) T cell immunodominance hierarchy

Understanding T cell immunodominance hierarchies is fundamental to the development of cellular-based vaccines and immunotherapy. A combination of influenza virus infection in C57BL/6J mice and reverse genetics is used here to dissect the role of T cell antigen receptor (TCR) repertoire in the immuno...

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Detalhes bibliográficos
Main Authors: Kedzierska, Katherine, Guillonneau, Carole, Gras, Stephanie, Hatton, Lauren A., Webby, Richard, Purcell, Anthony W., Rossjohn, Jamie, Doherty, Peter C., Turner, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2614774/
https://ncbi.nlm.nih.gov/pubmed/19047637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0810274105
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