Narrowed TCR repertoire and viral escape as a consequence of heterologous immunity

Why some virus-specific CD8 TCR repertoires are diverse and others restricted or “oligoclonal” has been unknown. We show here that oligoclonality and extreme clonal dominance can be a consequence of T cell cross-reactivity. Lymphocytic choriomeningitis virus (LCMV) and Pichinde virus (PV) encode NP(...

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Autori principali: Cornberg, Markus, Chen, Alex T., Wilkinson, Lee A., Brehm, Michael A., Kim, Sung-Kwon, Calcagno, Claudia, Ghersi, Dario, Puzone, Roberto, Celada, Franco, Welsh, Raymond M., Selin, Liisa K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2006
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1435724/
https://ncbi.nlm.nih.gov/pubmed/16614754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI27804
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