Protective Efficacy of Cross-Reactive CD8(+) T Cells Recognising Mutant Viral Epitopes Depends on Peptide-MHC-I Structural Interactions and T Cell Activation Threshold

Emergence of a new influenza strain leads to a rapid global spread of the virus due to minimal antibody immunity. Pre-existing CD8(+) T-cell immunity directed towards conserved internal viral regions can greatly ameliorate the disease. However, mutational escape within the T cell epitopes is a subst...

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Detalhes bibliográficos
Main Authors: Valkenburg, Sophie A., Gras, Stephanie, Guillonneau, Carole, La Gruta, Nicole L., Thomas, Paul G., Purcell, Anthony W., Rossjohn, Jamie, Doherty, Peter C., Turner, Stephen J., Kedzierska, Katherine
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2920842/
https://ncbi.nlm.nih.gov/pubmed/20711359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1001039
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