Lack of Heterologous Cross-reactivity toward HLA-A*02:01 Restricted Viral Epitopes Is Underpinned by Distinct αβT Cell Receptor Signatures

αβT cell receptor (TCR) genetic diversity is outnumbered by the quantity of pathogenic epitopes to be recognized. To provide efficient protective anti-viral immunity, a single TCR ideally needs to cross-react with a multitude of pathogenic epitopes. However, the frequency, extent, and mechanisms of...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Grant, Emma J., Josephs, Tracy M., Valkenburg, Sophie A., Wooldridge, Linda, Hellard, Margaret, Rossjohn, Jamie, Bharadwaj, Mandvi, Kedzierska, Katherine, Gras, Stephanie
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2016
Ämnen:
Immunology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5114392/
https://ncbi.nlm.nih.gov/pubmed/27645996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.753988
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