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Structural and Functional Correlates of Enhanced Anti-viral Immunity Generated by Heteroclitic CD8 T Cell Epitopes()
Peptides that bind poorly to MHC class I molecules often elicit low functional avidity T cell responses. Peptide modification by altering the anchor residue facilitates increased binding affinity and may elicit T cells with increased functional avidity towards the native epitope (“heteroclitic”). Th...
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| Principais autores: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4052115/ https://ncbi.nlm.nih.gov/pubmed/24795457 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1400111 |
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