Multiplex Screening Assay for Identifying Cytotoxic CD8(+) T Cell Epitopes

The cytotoxicity of epitope-specific CD8(+) T cells is usually measured indirectly through IFNγ production. Existing assays that directly measure this activity are limited mainly to measurements of up to two specificities in a single reaction. Here, we develop a multiplex cytotoxicity assay that all...

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Dettagli Bibliografici
Pubblicato in:Front Immunol
Autori principali: Poh, Chek Meng, Zheng, Jian, Channappanavar, Rudragouda, Chang, Zi Wei, Nguyen, Thi H. O., Rénia, Laurent, Kedzierska, Katherine, Perlman, Stanley, Poon, Leo L. M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7078160/
https://ncbi.nlm.nih.gov/pubmed/32218786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00400
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