CNS Amyloid-β, Soluble APP-α and -β Kinetics during BACE Inhibition

BACE, a β-secretase, is an attractive potential disease-modifying therapeutic strategy for Alzheimer's disease (AD) as it results directly in the decrease of amyloid precursor protein (APP) processing through the β-secretase pathway and a lowering of CNS amyloid-β (Aβ) levels. The interaction o...

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Détails bibliographiques
Auteurs principaux: Dobrowolska, Justyna A., Michener, Maria S., Wu, Guoxin, Patterson, Bruce W., Chott, Robert, Ovod, Vitaliy, Pyatkivskyy, Yuriy, Wildsmith, Kristin R., Kasten, Tom, Mathers, Parker, Dancho, Mandy, Lennox, Christina, Smith, Brad E., Gilberto, David, McLoughlin, Debra, Holder, Daniel J., Stamford, Andrew W., Yarasheski, Kevin E., Kennedy, Matthew E., Savage, Mary J., Bateman, Randall J.
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2014
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4051982/
https://ncbi.nlm.nih.gov/pubmed/24920637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0540-14.2014
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