Diurnal Patterns of Soluble Amyloid Precursor Protein Metabolites in the Human Central Nervous System

The amyloid-β (Aβ) protein is diurnally regulated in both the cerebrospinal fluid and blood in healthy adults; circadian amplitudes decrease with aging and the presence of cerebral Aβ deposits. The cause of the Aβ diurnal pattern is poorly understood. One hypothesis is that the Amyloid Precursor Pro...

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Main Authors: Dobrowolska, Justyna A., Kasten, Tom, Huang, Yafei, Benzinger, Tammie L. S., Sigurdson, Wendy, Ovod, Vitaliy, Morris, John C., Bateman, Randall J.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3960093/
https://ncbi.nlm.nih.gov/pubmed/24646516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089998
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