Increased in vivo Amyloid-β42 production, exchange, and irreversible loss in Presenilin Mutations Carriers

Alzheimer’s disease is hypothesized to be caused by an over-production or reduced clearance of amyloid-beta (Aβ) peptide. Autosomal Dominant Alzheimer’s Disease (ADAD) caused by mutations in the presenilin (PSEN) gene have been postulated to result from increased production of Aβ42 compared to Aβ40...

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Main Authors: Potter, Rachel, Patterson, Bruce W., Elbert, Donald L., Ovod, Vitaliy, Kasten, Tom, Sigurdson, Wendy, Mawuenyega, Kwasi, Blazey, Tyler, Goate, Alison, Chott, Robert, Yarasheski, Kevin E., Holtzman, David M., Morris, John C., Benzinger, Tammie L. S., Bateman, Randall J.
Format: Artigo
Language:Inglês
Published: 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3838868/
https://ncbi.nlm.nih.gov/pubmed/23761040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3005615
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