CNS Amyloid-β, Soluble APP-α and -β Kinetics during BACE Inhibition

BACE, a β-secretase, is an attractive potential disease-modifying therapeutic strategy for Alzheimer's disease (AD) as it results directly in the decrease of amyloid precursor protein (APP) processing through the β-secretase pathway and a lowering of CNS amyloid-β (Aβ) levels. The interaction o...

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Main Authors: Dobrowolska, Justyna A., Michener, Maria S., Wu, Guoxin, Patterson, Bruce W., Chott, Robert, Ovod, Vitaliy, Pyatkivskyy, Yuriy, Wildsmith, Kristin R., Kasten, Tom, Mathers, Parker, Dancho, Mandy, Lennox, Christina, Smith, Brad E., Gilberto, David, McLoughlin, Debra, Holder, Daniel J., Stamford, Andrew W., Yarasheski, Kevin E., Kennedy, Matthew E., Savage, Mary J., Bateman, Randall J.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4051982/
https://ncbi.nlm.nih.gov/pubmed/24920637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0540-14.2014
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