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Differential regulation of proteasome functionality in reproductive vs. somatic tissues of Drosophila during aging or oxidative stress

Proteasome is central to proteostasis maintenance, as it degrades both normal and damaged proteins. Herein, we undertook a detailed analysis of proteasome regulation in the in vivo setting of Drosophila melanogaster. We report that a major hallmark of somatic tissues of aging flies is the gradual ac...

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Detalhes bibliográficos
Main Authors: Tsakiri, Eleni N., Sykiotis, Gerasimos P., Papassideri, Issidora S., Gorgoulis, Vassilis G., Bohmann, Dirk, Trougakos, Ioannis P.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4050428/
https://ncbi.nlm.nih.gov/pubmed/23457214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-221408
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