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Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in a Drosophila model of Parkinson’s disease

Parkinson’s disease (PD) is the most common neurodegenerative movement disorder. Oxidative stress has been associated with the etiology of both sporadic and monogenic forms of PD. The transcription factor Nrf2, a conserved global regulator of cellular antioxidant responses, has been implicated in ne...

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書目詳細資料
Main Authors: Barone, Maria Cecilia, Sykiotis, Gerasimos P., Bohmann, Dirk
格式: Artigo
語言:Inglês
出版: The Company of Biologists Limited 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3180234/
https://ncbi.nlm.nih.gov/pubmed/21719443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.007575
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