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Declining signal-dependence of Nrf2-MafS regulated gene expression correlates with aging phenotypes

Aging is a degenerative process characterized by declining molecular, cell and organ functions, and accompanied by the progressive accumulation of oxidatively damaged macromolecules. This increased oxidative damage may be causally related to an age-associated dysfunction of defense mechanisms, which...

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Autori principali: Rahman, M. Mahidur, Sykiotis, Gerasimos P., Nishimura, Mayuko, Bodmer, Rolf, Bohmann, Dirk
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3714369/
https://ncbi.nlm.nih.gov/pubmed/23521918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12078
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