Differential regulation of proteasome functionality in reproductive vs. somatic tissues of Drosophila during aging or oxidative stress

Proteasome is central to proteostasis maintenance, as it degrades both normal and damaged proteins. Herein, we undertook a detailed analysis of proteasome regulation in the in vivo setting of Drosophila melanogaster. We report that a major hallmark of somatic tissues of aging flies is the gradual ac...

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Hauptverfasser: Tsakiri, Eleni N., Sykiotis, Gerasimos P., Papassideri, Issidora S., Gorgoulis, Vassilis G., Bohmann, Dirk, Trougakos, Ioannis P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Federation of American Societies for Experimental Biology 2013
Schlagworte:
Research Communications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4050428/
https://ncbi.nlm.nih.gov/pubmed/23457214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-221408
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