RASSF6 promotes p21(Cip1/Waf1)-dependent cell cycle arrest and apoptosis through activation of the JNK/SAPK pathway in clear cell renal cell carcinoma

Clear cell renal cell carcinoma (ccRCC) is a highly aggressive and common pathological subtype of renal cancer. This cancer is characterized by biallelic inactivation of the von Hippel–Lindau (VHL) tumor suppressor gene, which leads to the accumulation of hypoxia-inducible factors (HIFs). Although t...

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Autores principales: Liang, Ying-Ying, Zheng, Li-Sheng, Wu, Yuan-Zhong, Peng, Li-Xia, Cao, Yun, Cao, Xue, Xie, Ping, Huang, Bi-Jun, Qian, Chao-Nan
Formato: Artigo
Lenguaje:Inglês
Publicado: Landes Bioscience 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4050141/
https://ncbi.nlm.nih.gov/pubmed/24626183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.28416
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