RASSF6 promotes p21(Cip1/Waf1)-dependent cell cycle arrest and apoptosis through activation of the JNK/SAPK pathway in clear cell renal cell carcinoma

Clear cell renal cell carcinoma (ccRCC) is a highly aggressive and common pathological subtype of renal cancer. This cancer is characterized by biallelic inactivation of the von Hippel–Lindau (VHL) tumor suppressor gene, which leads to the accumulation of hypoxia-inducible factors (HIFs). Although t...

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Bibliografiske detaljer
Main Authors: Liang, Ying-Ying, Zheng, Li-Sheng, Wu, Yuan-Zhong, Peng, Li-Xia, Cao, Yun, Cao, Xue, Xie, Ping, Huang, Bi-Jun, Qian, Chao-Nan
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2014
Fag:
Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4050141/
https://ncbi.nlm.nih.gov/pubmed/24626183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.28416
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