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An in vitro evolved glmS ribozyme has the wildtype fold but loses coenzyme dependence

Uniquely among known ribozymes, the glmS ribozyme-riboswitch requires a small-molecule coenzyme, glucosamine-6-phosphate (GlcN6P). Although consistent with its gene-regulatory function, use of GlcN6P is unexpected because all other characterized self-cleaving ribozymes employ RNA functional groups o...

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Autores principales: Lau, Matthew W. L., Ferré-D’Amaré, Adrian R.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4049112/
https://ncbi.nlm.nih.gov/pubmed/24096303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1360
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