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Use of a coenzyme by the glmS ribozyme-riboswitch suggests primordial expansion of RNA chemistry by small molecules

The glmS ribozyme-riboswitch is the first known example of a naturally occurring catalytic RNA that employs a small molecule as a coenzyme. Binding of glucosamine-6-phosphate (GlcN6P) activates self-cleavage of the bacterial ribozyme, which is part of the mRNA encoding the metabolic enzyme GlcN6P-sy...

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Библиографические подробности
Главный автор: Ferré-D'Amaré, Adrian R.
Формат: Artigo
Язык:Inglês
Опубликовано: The Royal Society 2011
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3158913/
https://ncbi.nlm.nih.gov/pubmed/21930586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2011.0131
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