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Use of a coenzyme by the glmS ribozyme-riboswitch suggests primordial expansion of RNA chemistry by small molecules
The glmS ribozyme-riboswitch is the first known example of a naturally occurring catalytic RNA that employs a small molecule as a coenzyme. Binding of glucosamine-6-phosphate (GlcN6P) activates self-cleavage of the bacterial ribozyme, which is part of the mRNA encoding the metabolic enzyme GlcN6P-sy...
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The Royal Society
2011
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| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3158913/ https://ncbi.nlm.nih.gov/pubmed/21930586 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2011.0131 |
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