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The glmS ribozyme tunes the catalytically critical pK(a) of its coenzyme glucosamine-6-phosphate
The glmS ribozyme-riboswitch is the first known natural catalytic RNA that employs a small molecule cofactor. Binding of glucosamine-6-phosphate (GlcN6P) uncovers the latent self-cleavage activity of the RNA, which adopts a catalytically competent conformation, which is nonetheless inactive, in the...
Tallennettuna:
| Päätekijät: | , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2011
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3174766/ https://ncbi.nlm.nih.gov/pubmed/21848325 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja205185g |
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