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An in vitro evolved glmS ribozyme has the wildtype fold but loses coenzyme dependence
Uniquely among known ribozymes, the glmS ribozyme-riboswitch requires a small-molecule coenzyme, glucosamine-6-phosphate (GlcN6P). Although consistent with its gene-regulatory function, use of GlcN6P is unexpected because all other characterized self-cleaving ribozymes employ RNA functional groups o...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4049112/ https://ncbi.nlm.nih.gov/pubmed/24096303 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1360 |
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